Saturday, February 11, 2012

Jun turnover is controlled through JNK-dependent phosphorylation of theE3 ligase Itch.


Science. 2004 Oct 8;306(5694):271-5. Epub 2004 Sep 9.

Jun turnover is controlled through JNK-dependent phosphorylation of theE3 ligase Itch.

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Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0723, USA.


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A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.


Mol Cell. 2004 Jun 4;14(5):571-83.

A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.

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Gene Transfer Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Largo R. Benzi 10, 16132 Genoa, Italy. rgherzi@yahoo.com



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The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.


Cell. 2006 Feb 10;124(3):601-13.

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.


Division of Cancer Immunotherapeutics & Tumor Immunology, Beckman Research Institute at City of Hope, City of Hope National Medical Center, 1500 E. Duarte Road, KCRB 3009, Duarte, CA 91010, USA.

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Cells in Fig.3D look very similar to cells in Fig.4A, but they are supposed to be of different genotypes, and transfected and treated differently.
http://imgur.com/2A2CUHV




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In Fig. 1A, the 12.5 day WT and double mutant embryos are the same. See the identical light reflections. 

http://i.imgur.com/oEWRbgg.png


Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin.


Nature. 2007 Apr 5;446(7136):690-4. Epub 2007 Mar 18.

Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin.

Source

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Cancer Center, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA.

Erratum in

  • Nature. 2009 Feb 12;457(7231):920.

It has come to our attention that some of the control lanes in Fig. 2a (Kai1 and Mkk4 control lanes) may 
have been inadvertently duplicated during figure assembly; 
the other control lanes and the experimental Maspin lanes are correct. 
We have therefore repeated the experiments and obtained the same results as those in the published figure. 
The primary data from this experiment can be found in Supplementary Information. 



どこが複製されている画像なのでしょうか?

Alternative and classical NF-kappa B signaling retain autoreactive B cells in thesplenic marginal zone and result in lupus-like disease.


Immunity. 2006 Sep;25(3):403-15.

Alternative and classical NF-kappa B signaling retain autoreactive B cells in thesplenic marginal zone and result in lupus-like disease.

Source

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.





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